We are now in an era of integrated Biomedical Engineering and Medicine. This paper is about the new format of Medical Colleges (or Medical Schools) in which all subjects from anatomy and physiology to medicine and surgery would be structured by STEM. Together, this formatting of subjects can transform medicine into a STEM format of Medicine or STEM2, which can be incorporated into both education and healthcare delivery.

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The objective of this paper is to open a new frontier in (i) the science and practice of meditation, (ii) the physiological and spiritual benefits of meditation, and (iii) how meditation enables us to become global citizens and become dedicated to promoting progressive living for all the people in the world. We first present the new science paradigm of Cosmic Consciousness to cosmology, to life origin and evolution. Then, we explain how meditation ideating on Consciousness promotes psychosomatic health and wellbeing. Subsequently, we present the morality foundation of spirituality. Morality comprises Yama (controlling our actions) and Niyama (self-regulation), which are moral guidelines for human development. Morality and spirituality are intertwined. Without morality, we cannot develop spirituality. Meditation strengthens our morality.

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Momordica charantia L. (Family: Cucurbitaceae) is the most famous and highly appraised species loaded with a number of beneficial aspects in terms of health and disease, capable of exhibiting several therapeutic activities that have been utilized in the ancient mode of medication for treating health-related problems. Although many active compounds like Charantin derived from spices has been shown to have promising effect on therapeutics in terms of preventing and treating several diseases.

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Epilepsy is known to present with numerous neuro-psychiatric morbidities, one of which is intracranial Epidermoid Cyst. Lack of adequate knowledge about illness and treatment modalities is seen to be a cause of secondary emotional problems and poor medication adherence in the patients, causing further morbidity and poor prognostic outcome. This case reports and discusses the importance of timely detection of underlying organicity and optimal pharmacological management in a case of resistant epilepsy. It also aims to highlight the crucial role of non-pharmacological (psycho-educational) programs in maximising treatment outcome in these patients.

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Paediatric age group is most prone to the injuries as the child develop skills from daily routine to more complex activates. A large number of injuries, however, heal and some may leave a mark. Traumatic cataract is thus, one of the cause of ocular trauma and a preventable vision loss in children, when presented before a permanent damage and complication. This case reports the management of a case 12 year old female child belonging to rural area with unilateral poor vision following an ocular trauma which was left untreated for four years.

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Due to its increasing rate of incidence, stroke is being increasingly recognized as the major cause of death and disability in survivors across the world. Stroke survivors and their caregivers often experience numerous functional daily life activities challenges and limitations after discharging from hospital. Stroke is a family disease and considerable empirical evidence regarding post-stroke management consistently highlights the crucial role of psychosocial interventions in facilitating overall recovery process. Especially, the holistic approach in the post stroke management and rehabilitation of these patients has led to a considerable reduction in the burden of stroke care worldwide. The present review will add the new horizon in existing understanding and guide the future research attempts for the development of new psychosocial paradigms for promoting the optimal rehabilitation of stroke survivors and their careers.

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Phosphodiesterase inhibitors are class of drugs, actively inhibiting the specific target Phosphodiesterase Enzymes (PDE).FDA approved to be used in myriad of disorders such as Chronic Obstructive Pulmonary Disease (COPD), Erectile Dysfunction (ED), Benign Prostatic Hyperplasia (BPH), Pulmonary Artery Hypertension (PAH), Bronchial Asthma (BA) etc. The primary mechanism of PDE Inhibitors is smooth muscle relaxation and bronchodilation by inhibiting Cyclic Guanosine Monophosphate (cGMP) and Cyclic Adenosine Monophosphate (cAMP) degradation by acting on Nitric Oxide (NO) led pathway. This role of PDE Inhibitors is beneficial in so many conditions, as cGMP and cAMP pathways are present in numerous areas. We present a review on current state uses of PDE Inhibitors and their potential future therapy of experimental uses having off label effects utilising the Nitric Oxide led pathways as the core basis.

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Food and nutrients either directly or indirectly through genetic variation in the humans can lead to pathogenesis of a variety of diseases, including cardiometabolic, psychosomatic, somato-psychic and even malignant aliments. Though, nutrients and foods usually interact with genes in a benign manner, but sometimes, this interaction can have fatal outcomes”1 Therefore, diet, genetics and disease studies are gaining significance world over with the coming up of ever newer evidences that “nutrition can contribute to disease pathogenesis directly as well as indirectly genetic variation2.Increasing number of cardiometabolic deaths are largely linked to eating habits of people. Nutrigenomic and nutrigenetic studies have been

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