The present study was conducted to evaluate the prevalence of aspirin resistance in patients with IHD living in and around Udaipur. Fifty patients of IHD (Group I) either of healed myocardial infarction (>6 months) or angina in whom ischemia can be induced by TMT, and were taking 150 mg of aspirin daily for more than 3 months were selected. Fifty healthy individuals (Group II) were selected as control to know the baseline platelet aggregation in the same age group. Platelet aggregation was assessed employing platelet rich plasma (PRP) on optical aggregometer- ELVI 840.

01-14

A retrospective study showing a difference in neurotuberculosis patients receiving ATT and another group receiving ATT+ corticosteroids for 4-6 weeks in tapering doses was done in IPD patients of GBH General Hospital. The results were consistent with other authors that in patients receiving ATT+ steroids, the recovery was better & smooth without significant side effects

15-17

Neurofibromatosis type 1(NF1), is an autosomal dominant inherited disorder characterized by numerous cutaneous neurofibromas, intertriginous freckling, dermal and plexiform neurofibromas and cafe-au-lait spots1. Cerebrovascular disease in the setting of NF 1 is a rare entity. Among the rare cerebrovascular abnormalities, the most common is occlusion of the small cerebral arteries leading to infarcts. Intracranial aneurysms are quite uncommon with only few cases reported worldwide. It is hypotheised that the pathogenesis may be attributable to the proliferation of Schwann cells and the subsequent degeneration in the adjoining vessel wall. We hereby report an uncommon case of NF1 associated with massive intracerebral haemorrhage most likely caused by vessel wall rupture.

18-20

Formal thought disorder (FTD) has been a subject of interest for phenomenologists for a long time. Ever since Bleuler introduced the concept of "loosening of associations," it has been recognized as a fundamental symptom of psychosis. The understanding of FTD has evolved over time, and we now know that it involves a range of cognitive and linguistic abnormalities. While it was originally believed to be exclusive to schizophrenia, it is now acknowledged that FTD can also occur in affective psychoses, non-psychotic disorders, and even in individuals without any psychiatric conditions. Despite some promising research findings about FTD, there is still a lot that remains unknown or undiscovered about this symptom. One of the challenges in studying FTD is its clinical diversity, as its core clinical characteristics have not been definitively established. This sparks interest in this case of a 45 year old woman presented with chief complaints of irrelevant and incoherent thought with marked disturbances in verbal communication that had typical markers of symptoms that characterise a disruption in the expression and organisation of ideas and thoughts.

21-23

A class of metabolic disorders known as diabetes is referred by hyperglycemia brought on by abnormalities in insulin production. Postprandial hyperglycemia is ultimately caused by the breakdown of starch by α-amylase, which also generates glucose. One possible treatment strategy for diabetes mellitus involves blocking the α-amylase enzyme to reduce postprandial increase in blood glucose levels. Many of the anti-diabetic drugs such as voglibose, acarbose, and miglitol act as α- amylase inhibitors. Nevertheless, their costs are high and their applications come with unfavourable consequences. Several studies demonstrated the efficacy, safety, and acceptance of natural products and medicinal plants as useful sources of novel anti-diabetic medicines with a strong ability to suppress α-amylase enzyme activity. Therefore, an overview is conducted to find out the plants having in vitro α-amylase inhibitory activity. The analysis of the data reveals that several plant extracts have α-amylase inhibitory activity, which is quite comparable to the standard anti-diabetic drug. Notably, most of the studies have been carried out in recent years indicating the growing interest among researchers to find safer and more effective α-amylase inhibitors from plants.

24-39

This review delves into the transformative realm of translational research in psychiatric medicine, acting as the critical conduit between laboratory discoveries and practical applications in clinical settings. Employing a multidisciplinary approach, this process fosters collaboration among researchers, clinicians, and stakeholders to address the intricate complexities of mental health disorders. Emphasizing the significance of translational research, we explore its role in translating genetic insights and neurobiological discoveries into targeted interventions, ultimately enhancing patient care and treatment outcomes. Real-world applications are illuminated through examples, showcasing the tangible impact of translational efforts on treatment protocols. By addressing treatment gaps and tailoring interventions based on individual characteristics, this review underscores the shift toward personalized, patient-centered psychiatric care.

40-42

Thrombocytosis, also called thrombocythemia, is generally defined as platelet count greater than a defined upper limit of normal. The most common cut off for normal is <450,000/μl. Elevated platelet counts are often an incidental or unexpected finding on a complete blood count conducted to evaluate an unrelated condition. The causes of thrombocytosis are separated into two categories: autonomous (primary) thrombocytosis and reactive (secondary) thrombocytosis. Autonomous thrombocytosis occurs as a result of myeloproliferative disorders, myelodysplastic disorders, or rarely as a result of a hereditary condition. Reactive thrombocytosis is most often a normal physiologic response to coexistent chronic inflammatory conditions. Distinction between these two categories is important since autonomous thrombocytosis is associated with a significantly increased risk for thrombotic or hemorrhagic complications whereas reactive thrombocytosis is not. The most common reason for an elevated platelet count is reactive thrombocytosis. The present review will discuss about the association of reactive thrombocytosis with different clinical conditions and the possible underlying mechanism.

43-52

Vitamin D, the “sunshine vitamin” mainly benefits bones and muscles. Over the past few decades, it has generated lot of interest in scientific community regarding its extra skeletal health benefits. These benefits range from neurodegenerative diseases to metabolic conditions, cardiovascular disease, lung infection and cancer. The present short review will highlight its extra skeletal beneficial health effects in particular the present thinking on vitamin D and diabetes mellitus.

53-63

Hypnotherapy stands out among the many therapeutic modalities as a fascinating and multifaceted method that provides a deep dive into the complex interactions between the conscious and subconscious minds. The review aims at advancing the current understanding of hypnotherapeutic procedure for clinical problems by focusing on the research evidence and the respective methodological limitations along with the benefits of this therapy. This review provides an introductory overview of hypnotherapy, clarifying its theoretical foundations, historical antecedents, and modern uses, while highlighting its transforming potential for those seeking deep healing and personal development. Furthermore, the short review also highlights the current challenges and directions for future studies.

64-67

68-69